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FISH, Chromosome 20q Deletion
Test Code10055
CPT Codes
88271 (x2), 88275
Preferred Specimen
3 mL bone marrow or 5 mL whole blood collected in sodium heparin (green-top) tube
Minimum Volume
1 mL bone marrow • 3 mL whole blood
Other Acceptable Specimens
Bone marrow or whole blood collected in: sodium heparin (royal blue-top) tube, or sodium heparin lead-free (tan-top) tube
Instructions
Clinical history/reason for referral is required with test order. Prior therapy and transplant history should be provided with test order.
Specimen viability decreases during transit. Send specimen to testing lab for viability determination. Do not freeze. Do not reject.
Note: 100-200 interphase nuclei are examined microscopically using fluorescence in situ hybridization (FISH) for deletion of chromosome band 20q12 which is a recurrent abnormality in myelodysplastic syndrome, myeloproliferative disorders, and acute myelogenous leukemia. This test is useful for evaluation of suboptimal specimens or when a variant or cryptic rearrangement is suspected.
If results are not possible, the test order may be canceled and replaced with a Cytogenetics Communication.
Specimen viability decreases during transit. Send specimen to testing lab for viability determination. Do not freeze. Do not reject.
Note: 100-200 interphase nuclei are examined microscopically using fluorescence in situ hybridization (FISH) for deletion of chromosome band 20q12 which is a recurrent abnormality in myelodysplastic syndrome, myeloproliferative disorders, and acute myelogenous leukemia. This test is useful for evaluation of suboptimal specimens or when a variant or cryptic rearrangement is suspected.
If results are not possible, the test order may be canceled and replaced with a Cytogenetics Communication.
Transport Temperature
Room temperature
Specimen Stability
Room temperature: See instruction
Refrigerated: See instruction
Frozen: See instructions
Refrigerated: See instruction
Frozen: See instructions
Methodology
Fluorescence in situ Hybridization (FISH)
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Setup Schedule
Set up: Daily; Report available: 5 days
Reference Range
See Laboratory Report
