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FISH, CML, ASS, 9q34 Deletion
Test Code38405
CPT Codes
88271, 88275
Preferred Specimen
3 mL bone marrow submitted in culture transport media
Minimum Volume
1 mL bone marrow • 3 mL whole blood
Other Acceptable Specimens
Bone marrow or whole blood collected in: sodium heparin (green-top) tube
Instructions
Clinical history/reason for referral is required with test order. Prior therapy and transplant history should be provided.
Bone marrow (preferred) 1-3 mL, or whole blood 3-5 mL. Green vacutainer (sodium heparin only). Ship at room temperature. Bone marrow transport medium is available upon request.
Specimen viability decreases during transit. Send specimen to testing lab for viability determination. Do not reject.
Note: If results are not possible, the test order may be canceled and replaced with a Cytogenetics Communication.
Bone marrow (preferred) 1-3 mL, or whole blood 3-5 mL. Green vacutainer (sodium heparin only). Ship at room temperature. Bone marrow transport medium is available upon request.
Specimen viability decreases during transit. Send specimen to testing lab for viability determination. Do not reject.
Note: If results are not possible, the test order may be canceled and replaced with a Cytogenetics Communication.
Transport Temperature
Room temperature
Specimen Stability
Room temperature: See instructions
Refrigerated: See instructions
Frozen: Unacceptable
Refrigerated: See instructions
Frozen: Unacceptable
Methodology
Fluorescence in situ Hybridization (FISH)
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Setup Schedule
Monday-Sunday Morning Report available: 5 Days
Reference Range
Interpretive report
Clinical Significance
Fluorescence in situ hybridization (FISH) is used to detect deletion of the ASS region of chromosome 9q34 using a single color DNA probe. This test is generally performed subsequent to bcr/abl translocation FISH analysis in which a variant probe pattern was observed.
