Chromosome Analysis, Chorionic Villus Sample

Test Code

14592

CPT Codes
88235, 88267, 88280

Physician Attestation of Informed Consent

This germline genetic test requires physician attestation that patient consent has been received if ordering medical facility is located in AK, DE, FL, GA, IA, MA, MN, NV, NJ, NY, OR, SD or VT or test is performed in MA.

Preferred Specimen

40 mg chorionic villi in Hanks', Ringer's solution or culture medium with antibiotics

Minimum Volume

20 mg

Instructions

Ship in sterile container in Hanks', Ringer's solution or culture medium with antibiotics. CVS media available upon request. Ship at room temperature.

Please contact the laboratory Genetic Counselor at 1-866-GENEINFO (1-866-436-3463) with any questions.

Specimen viability decreases during transit. Send specimen to testing lab for viability determination. Do not freeze. Do not reject.

Transport Temperature

Room temperature

Specimen Stability

Room temperature: Preferred
Refrigerated: Acceptable
Frozen: Unacceptable

Methodology
Culture • Microscopy • Karyotype

Setup Schedule

Set up: Mon-Sat; Report available: 8 days

Limitations

Chromosome aberrations observed in the CVS specimen but not in the fetus (confined placental mosaicism) occurs in approximately 1% of cases.

Reference Range

Interpretive report

Clinical Significance

This test will detect chromosome abnormalities of the fetus including numerical, structural, and mosaic abnormalities. Chromosome analysis will also reveal fetal gender and sex chromosome abnormalities. Indications for prenatal chromosome analysis may include advanced maternal age, abnormal fetal ultrasound, abnormal maternal serum screen, abnormal cell-free DNA results, history of a previous child with a chromosome abnormality, or a parent who carries a balanced chromosomal rearrangement or has another chromosome abnormality.

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.