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Angiotensin II Type 1 Receptor (AGTR1) Gene 1166A>C Polymorphism
Test Code11118
CPT Codes
81400
Preferred Specimen
5 mL whole blood collected in an EDTA (lavender-top) tube
Minimum Volume
3 mL
Other Acceptable Specimens
Whole blood collected in an ACD solution B (yellow-top) tube, or sodium heparin (green-top) tube, or lithium heparin (green-top) tube
Instructions
Normal phlebotomy procedure. Specimen stability is crucial. Store and ship at room temperature immediately. Do not freeze.
Transport Temperature
Room temperature
Specimen Stability
Room temperature: 8 days
Refrigerated: 8 days
Frozen: Unacceptable
Refrigerated: 8 days
Frozen: Unacceptable
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Call laboratory if blood samples received frozen
Methodology
Polymerase Chain Reaction (PCR) • Single Nucleotide Primer Extension
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Setup Schedule
Wednesday, Saturday Morning Report available: 7 Days
Reference Range
Negative
Clinical Significance
The ATR1 receptor gene polymorphism is associated with increased risk for hypertension and cardiovascular risk. Substantial increase in the c allele frequency was observed among patients with severe hypertension, particularly among individuals carrying DD ACE genotype.