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Chromosome Analysis, Hematologic Malignancy
Test Code14600
CPT Codes
88237, 88264
Preferred Specimen
10 mL whole blood or 3 mL bone marrow collected in a sodium heparin (green-top) tube
Infants: 2-3 mL whole blood collected in a pediatric (3 mL) vacutainer
Infants: 2-3 mL whole blood collected in a pediatric (3 mL) vacutainer
Minimum Volume
1 mL
Other Acceptable Specimens
Bone marrow or whole blood collected in: sodium heparin (royal blue-top), or sodium heparin lead-free (tan-top) tubes
Instructions
Clinical history and reason for referral are required with test order. Previous bone marrow transplant or therapy information, if applicable, should be provided with test order.
Bone marrow: 3 mL or whole blood 10 mL, must contain 10% less mature myelocytes, pros, or blasts green vacutainer only. Infants 2-3 mL (in pediatric 3 mL vacutainer), must contain 10% myelocytes, pros or blasts. Ship at room temperature. Bone marrow transport medium is available upon request.
Note: See the "cytogenetics" section of the specimen collection guide for additional information. Other vacutainer tubes containing sodium heparin are acceptable.
This test may be replaced by one of the following if the completed test cannot be performed from the submitted specimen: a Tissue Culture for Hematologic Disorder code; or with a Cytogenetics Communication, if a communication is required.
Bone marrow: 3 mL or whole blood 10 mL, must contain 10% less mature myelocytes, pros, or blasts green vacutainer only. Infants 2-3 mL (in pediatric 3 mL vacutainer), must contain 10% myelocytes, pros or blasts. Ship at room temperature. Bone marrow transport medium is available upon request.
Note: See the "cytogenetics" section of the specimen collection guide for additional information. Other vacutainer tubes containing sodium heparin are acceptable.
This test may be replaced by one of the following if the completed test cannot be performed from the submitted specimen: a Tissue Culture for Hematologic Disorder code; or with a Cytogenetics Communication, if a communication is required.
Transport Temperature
Room temperature
Specimen Stability
Room temperature: See instructions
Refrigerated: See instructions
Frozen: See instructions
Refrigerated: See instructions
Frozen: See instructions
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Received frozen
Methodology
Culture • Karyotype • Microscopy
Setup Schedule
Set up: Mon-Sat; Report available: 8 days
Reference Range
See Laboratory Report
Clinical Significance
Cytogenetics of hematologic disorders attempts to define and interpret chromosomal aberrations that occur in neoplastic cells associated with leukemia, lymphoma and other hematologic malignancies. Chromosome abnormalities in cancer cells of patients with malignant hematologic disorders including acute and chronic myeloid and lymphoid leukemias, myelodysplastic and myeloproliferative disorders, lymphomas and unexplained anemias may correlate with the diagnosis, prognosis, treatment and etiology of disease.