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A B C D E F G H I J K L M N O P Q R S T U V W X Y Z # |
Toxoplasma gondii Antibodies (IgG, IgM), ELISA, CSF
Test CodeCPT Codes
86777, 86778
Preferred Specimen
Minimum Volume
Instructions
Transport Temperature
Room temperature
Specimen Stability
Refrigerated: 14 days
Frozen: 30 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Methodology
Enzyme Linked Immunosorbent Assay (ELISA)
Setup Schedule
Reference Range
Toxoplasma gondii (IgG) | <0.90 |
Toxoplasma gondii (IgM) | <0.80 |
Interpretive criteria
Toxoplasma gondii (IgG)
<0.90 | Antibody not detected |
0.90-1.09 | Equivocal |
≥1.10 | Antibody detected |
<0.80 | Antibody not detected |
0.80-0.99 | Equivocal |
≥1.00 | Antibody detected |
Clinical Significance
This antibody panel detects IgG and IgM against Toxoplasma gondii in the cerebrospinal fluid (CSF). This panel may be useful as part of a diagnostic evaluation for central nervous system (CNS) toxoplasmosis, especially in immunocompromised individuals [1]. The results of this test must be interpreted in conjunction with CSF-serum antibody ratios.
Toxoplasmosis is a parasitic infection caused by the protozoan T gondii. Immunocompetent individuals generally have no symptoms or flu-like symptoms that resolve within weeks or months. Immunocompromised individuals can have severe or even fatal toxoplasmosis, which most often involves the CNS [1].
Serologic testing is commonly used in diagnosing toxoplasmosis. However, immunocompromised patients can have low or undetectable serum levels of Toxoplasma-specific IgG antibodies. For immunocompromised patients with suspected CNS infection, testing CSF may provide evidence of CNS toxoplasmosis through direct observation of T gondii, detection of T gondii DNA (eg, by PCR), or demonstration of local production of Toxoplasma-specific antibodies [1].
The results of this test should be interpreted in the context of pertinent clinical history and physical examination findings.
Reference
1. McAuley JB, et al. Toxoplasma. In: Carroll KC, et al, eds. Manual of Clinical Microbiology. 12th ed. ASM Press; 2019. https://www.clinmicronow.org/doi/book/10.1128/9781683670438.MCM.ch141