FISH, B-cell Malignancy, IGH, 14q32 Rearrangement

Test Code

17348

CPT Codes
88275, 88271 (x2)

Includes

Note: If results are not possible, the test order may be canceled and replaced with a Cytogenetics Communication

Preferred Specimen

5 mL whole blood or 3 mL bone marrow collected in sodium heparin (green-top), sodium heparin (royal blue-top) or sodium heparin lead-free (tan-top) tube, or
5x5 mm fresh tissue collected in culture transport media or sterile container with Hanks' or Ringers solution, or
Tissue in Formalin-fixed paraffin-embedded tissue

Minimum Volume

1 mL whole blood or bone marrow • 5x5 tissue

Instructions

Clinical history and reason for referral are required with test order. Prior therapy and transplant history should be provided.
3-5 mL whole blood or 1-3 mL bone marrow collected in sodium heparin tube, 5x5 mm Fresh tissue in sterile container, Formalin Fixed Paraffin Embedded Tissue.

Specimen viability decreases during transit. Send specimen to testing laboratory for viability determination. Do not freeze. Do not reject.

Transport Temperature

Room temperature

Specimen Stability

Room temperature: See Instructions
Refrigerated: See Instructions
Frozen: See Instructions

Methodology
Fluorescence in situ Hybridization (FISH)

FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Setup Schedule

Monday-Sunday Evening
Report available: 5 Days

Reference Range

See Laboratory Report

Clinical Significance

The splitting of IgH region of chromosome 14q32 is frequently implicated in translocations seen in a variety of hematological malignancies of B-cell origin.

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.