Celiac Disease Comprehensive Panel with Gliadin Antibody (IgG)

Test Code

36336

CPT Codes
86364, 82784

Includes

Tissue Transglutaminase (tTG) Antibody (IgA)
IgA (Immunoglobulin A)

If Tissue Transglutaminase (tTG) Antibody (IgA) is Detected (≥15.0 U/mL), then Endomysial Antibody (IgA) Screen with Reflex to Titer will be performed at an additional charge (CPT code(s):86231).
If Endomysial Antibody (IgA) Screen is Positive, then Endomysial Antibody Titer will be performed at an additional charge (CPT code(s): 86231).

If Immunoglobulin A is flagged as low based on age appropriate reference range, or if no age is provided and Immunoglobulin A result is <47 mg/dL, then Tissue Transglutaminase (tTG) Antibody (IgG) and Gliadin (Deamidated) Antibody (IgG) will be performed at an additional charge (CPT code(s): 86364, 86258).

Preferred Specimen

5 mL serum

Minimum Volume

1 mL

Transport Temperature

Room temperature

Specimen Stability

Room temperature: 72 hours
Refrigerated: 7 days
Frozen: 21 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Gross hemolysis • Grossly lipemic

Methodology
Immunoassay (IA) • Immunoturbidimetric Assay

Setup Schedule

Set up and Report available: See individual tests

Reference Range

Tissue Transglutaminase (tTG) Antibody (IgA)

<15.0 U/mL	Antibody not detected
≥15.0 U/mL	Antibody detected

IgA (Immunoglobulin A)

Cord Blood

1-3 mg/dL

1-28 days

2-40 mg/dL

1-3 months

3-40 mg/dL

4-6 months

7-47 mg/dL

7-11 months

12-53 mg/dL

1 year

20-73 mg/dL

2 years

20-99 mg/dL

3-5 years

22-140 mg/dL

6-8 years

31-180 mg/dL

9-11 years

33-200 mg/dL

12-16 years

36-220 mg/dL

17-60 years

47-310 mg/dL

≥61 years

70-320 mg/dL

Clinical Significance

This panel is used to assist in the diagnosis of celiac disease (CD).
Background: CD is caused by an immune response to gluten in genetically sensitive individuals. Diagnosis begins with serologic testing and is confirmed by biopsy. This panel tests all specimens for tissue transglutaminase (tTG) IgA, which has 95% sensitivity and specificity for CD. Specimens positive for tTG IgA are tested for endomysial antibody (IgA), which may increase specificity for CD. This panel also tests all specimens for total IgA. A total IgA level below the reference range is suggestive of IgA deficiency and reflexes to IgG-based tests: tTG IgG and gliadin (deamidated) antibody (IgG); these tests are generally less sensitive than tTG IgA for CD but are useful in the context of IgA deficiency.

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.