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Venous Thrombosis Hypercoagulability Panel with Reflex and Consultation
Test CodeCPT Codes
85307, 81240, 85303, 85306, 85305, 85300, 83090, 86147 (x2), 85240, 86146 (x2), 85730, 85613 <br>Dependent on the complexity of the consultation, 80503 or 80504 or 80505 may be assigned. 80506 may also be billed if high complexity with more than 60 minutes of time spent for the consultation.
Includes
Prothrombin (Factor II) 20210G→A Mutation Analysis
Protein C Activity
Protein S Antigen, Free and Protein S Antigen, Total
Antithrombin III Activity
Homocysteine
Cardiolipin Antibodies (IgG, IgM)
Factor VIII Activity, Clotting
Beta-2-Glycoprotein I Antibodies (IgG, IgM)
Lupus Anticoagulant Evaluation with Reflex (PTT-LA and dRVVT with Reflex Confirmations)
Coagulation Consultation
If Activated Protein C-Resistance is <2.1 ratio, then Factor V (Leiden) Mutation Analysis will be performed at an additional charge (CPT code(s): 81241).
If PTT-LA Screen is prolonged (>40 seconds), then Hexagonal Phase Confirmation will be performed at an additional charge (CPT code(s): 85598).
If Hexagonal Phase Confirmation is positive or weakly positive, then Thrombin Clotting Time will be performed at an additional charge (CPT code(s): 85670.
If dRVVT Screen is prolonged (>45 seconds), then dRVVT Confirm will be performed at an additional charge (CPT code(s): 85597).
If dRVVT Confirm is positive, then dRVVT 1:1 Mixing Study will be performed at an additional charge (CPT code(s): 85613).
Preferred Specimen
1 mL frozen platelet-poor plasma (x6) collected in separate 3.2% sodium citrate (light-blue top) tubes, and
1 mL serum collected in a red-top tube (no gel)
Minimum Volume
Instructions
•Whole blood sample is for the Factor V Mutation Analysis and Prothrombin (Factor II) Mutation Analysis.
•Serum sample is for the Homocysteine.
Red top tubes: Place the specimen in a refrigerator or ice bath for 30 minutes after collection. Centrifuge the specimen as soon as possible after complete clot formation has taken place. Transfer the serum to a plastic screw-capped vial.
Barrier gel separator tubes: Place the specimen in a refrigerator for 30 minutes after collection. Centrifuge the specimen as soon as possible after complete clot formation has taken place. Do not place barrier tubes in an ice bath as freezing may prevent the barrier gel from adequately separating serum from cells. Platelet-poor plasma is for remaining tests.
Platelet-poor plasma: Centrifuge light blue-top tube 15 minutes at approximately 1500 x g within 60 minutes of collection. Using a plastic pipette, remove plasma, taking care to avoid the WBC/platelet buffy layer and place into a plastic vial. Centrifuge a second time and transfer platelet-poor-plasma into four plastic vials. Plasma must be free of platelets (<10,000/mcL). Freeze immediately and transport on dry ice.
Note: Storage of whole blood at refrigerated temperatures prior to processing may lead to cryoprecipitate formation and falsely low Factor VIII and von Willebrand Factor studies.
Transport Temperature
Plasma and serum: Frozen
Specimen Stability
Room temperature: 8 days
Refrigerated: 8 days
Frozen: 30 days
Serum
Room temperature: 4 days
Refrigerated: 14 days
Frozen: 6 months
Plasma
Room temperature: Unacceptable
Refrigerated: Unacceptable
Frozen: 14 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Methodology
See individual tests
Setup Schedule
Reference Range
Clinical Significance