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Thrombotic Marker Panel with Consultation
Test Code19685
CPT Codes
83520 (x2), 85362, 85379
Includes
D-Dimer, Fibrin Monomer, Prothrombin Fragment 1.2, Thrombin-Antithrombin (TAT) Complex
Please note: Consult performed at Quest Diagnostics, Chantilly, VA
Please note: Consult performed at Quest Diagnostics, Chantilly, VA
Preferred Specimen
2 mL platelet-poor plasma collected in each of three separate 3.2% sodium citrate (light blue-top) tubes
Minimum Volume
1 mL (x3)
Instructions
Centrifuge light blue-top tube 15 minutes at approximately 1500 g within 60 minutes of collection. Using a plastic pipette, remove plasma, taking care to avoid the WBC/platelet buffy layer and place into a plastic vial. Centrifuge a second time and transfer platelet-poor plasma into a new plastic vial. Plasma must be free of platelets (<10,000/mcL). Freeze immediately and ship on dry ice.
Transport Temperature
Frozen
Specimen Stability
Room temperature: Unacceptable
Refrigerated: Unacceptable
Frozen: 21 days
Refrigerated: Unacceptable
Frozen: 21 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Received room temperature • Received refrigerated • Gross hemolysis
Methodology
Enzyme Immunoassay • Hemagglutination
Setup Schedule
Set up and Report available: See individual assays
Reference Range
See Laboratory Report
Clinical Significance
When intravascular thrombosis is suspected in the absence of overt clinical symptoms, elevation in D-dimer, fibrin monomer, prothrombin fragment 1.2, or thrombin-antithrombin complex may be the only indicator of intravascular clot formation and generation of activated factor X. Marked elevation in only 1 or 2 of these markers should lead to further investigation of the site of the thrombosis (e.g., early dissecting aortic aneurysm, anomalous arterial/venous fistula).
