Lupus Anticoagulant and Antiphospholipid Confirmation (non Coumadin) without Consultation

Test Code

19652

CPT Codes
85613, 85730, 86146 (x2), 86147 (x2)

Includes

19648 - Prolonged aPTT Thrombotic Evaluation
36333 - Cardiolipin Antibodies (IgG, IgM)
36553 - Beta-2-Glycoprotein I Antibody (IgM)
36554 - Beta-2-Glycoprotein I Antibody (IgG)

Reflex Criteria:
If PTT-LA Screen is prolonged (> 40 seconds), then Hexagonal Phase Confirmation will be performed at an additional charge (CPT code(s): 85598).

If the dRVVT Screen is prolonged (> 45 seconds), the dRVVT Confirmation will be performed at an additional charge (CPT code(s): 85597).If the dRVVT Confirm is positive, a dRVVT 1:1 mix will be performed at an additional charge (CPT code(s): 85613).

If the Hexagonal Phase Confirm and DRVVT Confirm are negative, then Prothrombin Time (PT), Thrombin Clotting Time (TCT), and Fibrinogen Profile, will be performed at an additional charge (CPT code(s): 85384, 85610, 85670).

Preferred Specimen

1 mL frozen platelet-poor plasma (x6) collected in 3.2% sodium citrate (light blue-top) tubes

Minimum Volume

0.5 mL (x6)

Instructions

Please see the individual tests for specific specimen requirements, and stabilities.

Transport Temperature

Frozen

Specimen Stability

Room temperature: Unacceptable
Refrigerated: Unacceptable
Frozen: 14 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Gross hemolysis • Grossly lipemic • Received room temperature • Received refrigerated

Methodology
Immunoassay (IA)

Setup Schedule

Set up and Report available: See individual tests

Reference Range

See individual tests

Clinical Significance

This panel is useful for the investigation of a prolonged aPTT in a patient with a thrombotic history, and for providing laboratory evidence for antiphospholipid syndrome. The panel includes testing for cardiolipin and beta-2-glycoprotein I criteria antibodies and clotting based assays for lupus anticoagulant.

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.