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| A B C D E F G H I J K L M N O P Q R S T U V W X Y Z # |
17 Hydroxypregnenolone
Test Code8352
CPT Codes
84143
Preferred Specimen
2 mL serum collected in a red-top tube (no gel)
Minimum Volume
0.4 mL
Transport Temperature
Refrigerated (cold packs)
Specimen Stability
Room temperature: 24 hours
Refrigerated: 5 days
Frozen: 28 days
Refrigerated: 5 days
Frozen: 28 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Received room temperature • Serum separator tube (SST) • Gross hemolysis • Grossly lipemic • Grossly icteric
Methodology
Chromatography/Mass Spectrometry
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Setup Schedule
Set up: Sun-Fri; Report available: 3-6 days
Limitations
Infants with 21-hydroxylase deficiency may present with non-elevated results.
Reference Range
| Adult Males | ≤700 ng/dL |
Adult Females, Pre-Menopausal
| Mid Follicular | 38-378 ng/dL |
| Surge | 33-583 ng/dL |
| Mid Luteal | 70-470 ng/dL |
Pediatric Male and Female
| <30 days | ≤3013 ng/dL |
| 1-11 months | ≤869 ng/dL |
| 1 year | ≤557 ng/dL |
| 2 years | ≤487 ng/dL |
| 3 years | ≤541 ng/dL |
| 4 years | ≤561 ng/dL |
| 5 years | ≤564 ng/dL |
| 6 years | ≤561 ng/dL |
| 7 years | ≤549 ng/dL |
| 8 years | ≤569 ng/dL |
| 9 years | ≤590 ng/dL |
| 10 years | ≤594 ng/dL |
| 11 years | ≤629 ng/dL |
| 12 years | ≤666 ng/dL |
| 13 years | ≤678 ng/dL |
| 14 years | ≤706 ng/dL |
| 15 years | ≤735 ng/dL |
| 16 years | ≤739 ng/dL |
| 17 years | ≤756 ng/dL |
Clinical Significance
17-Hydroxypregnenolone is useful in the diagnosis of 3-Beta-Hydroxylase enzyme deficiency, a rare cause of congenital adrenal hyperplasia, and 17-Hydroxylase (P450c17) enzyme deficiency.
