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Cortisol, Total, LC/MS
Test Code11281
CPT Codes
82533
Preferred Specimen
1 mL serum collected in a red-top tube (no gel)
Minimum Volume
0.2 mL
Other Acceptable Specimens
Plasma collected in: EDTA (lavender-top) tube
Instructions
Specify time of day specimen was collected
Transport Temperature
Room temperature
Specimen Stability
Room temperature: 14 days
Refrigerated: 21 days
Frozen: 1 year
Refrigerated: 21 days
Frozen: 1 year
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis • Serum separator tube (SST)
Methodology
Chromatography/Mass Spectrometry
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Setup Schedule
Set up: Mon-Fri; Report available: 3-7 days
Reference Range
Adult | |
8:00 - 10:00 AM | 4.6-20.6 mcg/dL |
4:00 - 6:00 PM | 1.8-13.6 mcg/dL |
Cortisol Response to ACTH | |
Peak | >20.0 mcg/dL |
Peak | >16.0 mcg/dL after IM injection |
Pediatric
Age | mcg/dL |
Infants | |
Premature (31-35 weeks)** | ≤15.0 |
Term, 3 days old** | ≤14.0 |
<30 days | Not established |
1-11 months | 1.4-24.0 |
1 year | 1.7-25.4 |
2 years | 1.8-26.4 |
3 years | 2.0-27.0 |
4 years | 2.0-27.2 |
5 years | 2.0-27.3 |
6 years | 2.0-27.2 |
7 years | 2.0-27.1 |
8 years | 2.0-27.0 |
9 years | 1.9-26.8 |
10 years | 1.9-26.4 |
11 years | 1.8-26.1 |
12 years | 1.8-26.0 |
13 years | 1.8-26.1 |
14 years | 1.9-26.6 |
15 years | 2.1-27.5 |
16 years | 2.3-28.6 |
17 years | 2.6-29.8 |
ACTH Stimulation** | Baseline (mcg/dL) | 60 Minutes (mcg/dL) |
1-12 Months | 3.0-23.0 | 32.0-60.0 |
1-5 Years | 6.0-25.0 | 22.0-40.0 |
6-12 Years | 3.0-15.0 | 17.0-28.0 |
**Pediatric data from J Clin Endocrinol Metab
(1991) 73:674-686 and J Clin Endocrinol Metab
(1989) 69:1133-1136.
Clinical Significance
Total cortisol concentrations are decreased in Addison's Disease and increased in Cushing's Disease and in other conditions of glucocorticoid excess.