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Unstable Hemoglobin

Test Code
29385


CPT Codes
83068

Preferred Specimen
8 mL random whole blood collected in an EDTA (lavender-top) tube


Minimum Volume
3 mL


Transport Temperature
Refrigerated (cold packs)


Specimen Stability
Room temperature: 24 hours
Refrigerated: 7 days
Frozen: Unacceptable


Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Received room temperature


Methodology
Alcohol Precipitation

Setup Schedule
Set up: Daily; Report available: 1-5 days


Reference Range
None detected


Clinical Significance
Unstable hemoglobins result from mutations around the heme pocket as well as contact points between the individual globin subunits resulting in hemolytic anemia. Hemoglobins carrying these structural modifications may denature and precipitate when exposed to alcohol, such as isopropanol.




The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.