Chromosome Analysis and Alpha-Fetoprotein with Reflex to AchE and Fetal Hgb, Amniotic Fluid (NY) [17851X]

Test Code

17851

CPT Codes
88235, 88269, 88280, 82106<br /> **This test is for non-New York patient testing. For non-New York patient testing use test code 14591Z**

Physician Attestation of Informed Consent

This germline genetic test requires physician attestation that patient consent has been received if ordering medical facility is located in AK, DE, FL, GA, IA, MA, MN, NV, NJ, NY, OR, SD or VT or test is performed in MA.

Includes

Chromosome Analysis, Banded and Alpha-Fetoprotein (AFP) with Reflexes

If the AFP MoM is >1.99, Acetylcholinesterase and Fetal Hemoglobin will be performed at an additional charge (CPT code(s): 82664, 83033).

Preferred Specimen

20 mL amniotic fluid collected in a sterile screw-cap container

Minimum Volume

5 mL

Instructions

30 mL is preferred if other testing, e.g., microarray, FISH, is ordered

Ship at room temperature. Do not freeze.
Send all tubes to lab (supernatant for AFP will be split by cytogenetics lab).

Please contact the laboratory Genetic Counselor at 1-866-GENEINFO (1-866-436-3463) with any questions.

Specimen viability decreases during transit. Send specimen to testing lab for viability determination. Do not freeze. Do not reject.

If sample exceeds stability, please call laboratory at ext. 4307 for instructions.

Transport Temperature

Room temperature

Specimen Stability

Room temperature: Preferred
Refrigerated: Acceptable
Frozen: Unacceptable

Methodology
Culture • Microscopy • Karyotype • Gel Electrophoresis • Radial Immunodiffusion • AFP: Chemiluminescent

FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Setup Schedule

Set up: Mon-Fri; Report available: 9-12 days (additional days for reflex if needed)

Reference Range

See Medical Report

Clinical Significance

Prenatal detection of cytogenetic abnormalities, both numerical and structural, that may be associated with phenotypic and/or developmental abnormalities in the fetus. This test is also used to diagnose neural tube and ventral wall defects.

See Cytogenetics in the Genetics section of Test Application and Interpretation.

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.