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Procainamide
Test Code743
CPT Codes
80192
Includes
Procainamide, N-acetylprocainamide, and Procainamide, Total
Preferred Specimen
1 mL serum collected in a red-top tube (no gel)
Patient Preparation
Collect as a trough just before next dose.
Minimum Volume
0.2 mL
Other Acceptable Specimens
Plasma collected in: EDTA (lavender-top) tube, or sodium or lithium heparin (green-top) tube
Transport Temperature
Room temperature
Specimen Stability
Room temperature: 4 days
Refrigerated: 7 days
Frozen: Not established
Refrigerated: 7 days
Frozen: Not established
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Serum separator tube (SST)
Methodology
Immunoassay (IA)
Setup Schedule
Set up: Mon-Sat; Report available: Next day
Reference Range
See Laboratory Report
Clinical Significance
Procainamide is used to treat a variety of atrial and ventricular arrhythmias. Metabolism of procainamide produces an active metabolite N-Acetylprocainamide (NAPA). The concentration of both procainamide and NAPA levels are monitored to assure adequate therapeutic levels of procainamide are achieved and to avoid toxicity.