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Tobramycin, Peak and Trough [890X]
Test Code89088
CPT Codes
80200 (x2)
Preferred Specimen
1 mL serum collected in each of two separate red-top tubes (no gel)
Patient Preparation
Collect peak 30 minutes after end of IV infusion or 60-90 minutes after IM dose.
Collect as a trough just prior to next dose.
Minimum Volume
0.2 mL
Other Acceptable Specimens
Plasma collected in each of two separate: EDTA (lavender-top) tubes, sodium heparin (green-top) tubes, lithium heparin (green-top) tubes, 3.2% sodium citrate (light blue-top) tubes or fluoride/oxalate (gray-top) tubes
Transport Temperature
Room temperature
Specimen Stability
Room temperature: 7 days
Refrigerated: 7 days
Frozen: 7 days
Refrigerated: 7 days
Frozen: 7 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Serum separator tube
Methodology
Immunoassay (IA)
Setup Schedule
Set up: Mon-Sat; Report available: 1-2 days
Reference Range
Tobramycin, Peak | 5.0-10.0 mg/L | |
Tobramycin, Trough | 1.0-2.0 mg/L |
Clinical Significance
Tobramycin is an aminoglycoside antibiotic used in the treatment of gram-negative bacterial infections, especially Pseudomonas, Proteus, Klebsiella and also Staphylococcus. Tobramycin is potentially nephrotoxic and ototoxic and serial monitoring of peak and trough serum levels may provide the clinician with information to maintain safe and therapeutic levels.