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Amikacin, Peak and Trough
Test Code250
CPT Codes
80150 (x2)
Preferred Specimen
1 mL serum collected in each of two red-top tubes (no gel)
Patient Preparation
Collect peak at end of a 60 minute IV infusion, or 30 minutes after end of 30 minute infusion, or 60 minutes after IM dose.
Collect as a trough just prior to next dose.
Minimum Volume
0.2 mL
Other Acceptable Specimens
1 mL plasma collected in each of two EDTA (lavender-top) tubes, or fluoride oxalate (gray-top) tubes
Transport Temperature
Room temperature
Specimen Stability
Room temperature: 7 days
Refrigerated: 7 days
Frozen: 7 days
Refrigerated: 7 days
Frozen: 7 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Serum separator tube • Heparin plasma
Methodology
Immunoassay (IA)
Setup Schedule
Set up: Mon-Sat; Report available: 1-2 days
Reference Range
Amikacin, Peak | 20.0-30.0 mg/L |
Amikacin, Trough | 4.0-8.0 mg/L |
Clinical Significance
Amikacin is an aminoglycoside antibiotic used in the treatment of gram-negative bacillary infections. Amikacin is potentially nephrotoxic and ototoxic and serial monitoring of serum levels provides information to maintain safe and therapeutic levels.