Autoimmune Epilepsy Evaluation

Test Code

94605

CPT Codes
83519, 86255 (x3), 86341

Includes

GAD65 Autoantibody Test (Epilepsy)
VGKC Autoantibody Test (Epilepsy)
CASPR2 Autoantibody Test (Epilepsy)
LGI1 Autoantibody Test (Epilepsy)
NMDA Receptor Autoantibody Test (Epilepsy)

Preferred Specimen

2 mL serum

Minimum Volume

0.5 mL

Instructions

Note: Please label each specimen tube with two forms of patient identification. These forms of identification must also appear on the requisition form.
Serum must be separated from cells within 48 hours of collection.

Transport Container

Plastic screw-cap vial

Transport Temperature

Refrigerated (cold packs)

Specimen Stability

Room temperature: 72 hours
Refrigerated: 28 days
Frozen: 28 days

Methodology
Enzyme Linked Immunosorbent Assay (ELISA) • Immunofluorescence Assay (IFA) • Radioimmunoassay (RIA)

FDA Status
This test was developed and its analytical performance characteristics have been determined by Athena Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Setup Schedule

Set up: Mon, Thurs; Report available: 7-10 days

Reference Range

See Laboratory Report

Clinical Significance

Anti-GAD65 antibodies, anti-voltage gated potassium channels (VGKC), anti-CASPR2, anti-LGI1, and anti-NMDA receptor (NR1 subunit) antibodies are found in patients with epilepsy with an acute/subacute presentation without evidence of CNS infection, toxic, metabolic, or other known cause of epilepsy, and possibly with evidence of CNS inflammation.

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.