Drug Toxicology Benzodiazepines, with Confirmation, Oral Fluid

Test Code

93979

CPT Codes
80307

Includes

If screening drug class result is equal to or greater than the cutoff, then confirmation testing will be performed at an additional charge (CPT code(s): 80346; HCPCS: G0480).

Preferred Specimen

1 mL oral fluid inserted into 3 mL buffer tube collected in Quantisal™ device

Patient Preparation
Quantisal™: Avoid any food or drink consumption, or gum or tobacco use for 10 minutes prior to collecting. If donor's mouth is not empty immediately prior to collection, have subject rinse mouth with water (up to 4 oz) and wait a minimum of 10 minutes before collecting a specimen.

Minimum Volume

See specimen collection guidance for minimum

Instructions

Quantisal™: Using the standard Quantisal™ collection container, place the swab under the tongue. Donor should keep head down to allow gravity to help with saliva collection. Leave in place until blue dye indicates that the collection pad is saturated sufficiently. Follow collection instructions on package.

Transport Temperature

Room temperature

Specimen Stability

Room temperature: 10 days
Refrigerated: 30 days
Frozen: 30 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Specimens submitted in a non-Quantisal™ device • Specimens received with any food debris or foreign objects present in the sample • Multiple swabs present in a single device • No swab present with the device • Quantisal™: collection wand inverted inside the collection tube

Methodology
Mass Spectrometry (MS)

FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Setup Schedule

Set up: Daily; Report available: 3-5 days

Reference Range

See Laboratory Report

Clinical Significance

Oral fluid is composed of saliva, mixed with buccal and mucosal transudates, cellular debris, bacteria, and residue of ingested products. Oral fluid as a test matrix shows promise for detection of recent drug use, and a significant body of scientific literature documents drug disposition and detection times. Researchers comparing effectiveness of oral fluid and urine drug testing found a similar pattern and frequency of positive drug test results in the general workforce over the same general period. Similarly in pain clinics, the pattern of licit and illicit drugs and metabolites observed in oral fluid paralleled results reported for urine, with some minor differences in detection rates for different drug classes. In some cases, oral fluid testing may be an acceptable alternative or the only available matrix. As an ultra-filtrate of blood, however, it shares the limitations of a decreased window of detection versus conventional urine drug testing.

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.