PD-L1 Lung (Atezolizumab), IHC

Test Code

94480

CPT Codes
88360

Preferred Specimen

Formalin-fixed, paraffin-embedded tissue block, NSCLC, collected in an IHC specimen transport kit

Other Acceptable Specimens

Minimum 5 unstained positively charged slides submitted in an IHC specimen transport kit

Instructions

FFPE: State any other type of fixative used. A pathology report which includes the paraffin block number, and both macroscopic and microscopic evaluation and diagnosis, should be sent with the specimen.

Transport Temperature

Room temperature

Specimen Stability

Tissue block
Room temperature: 5 years
Refrigerated: 5 years
Frozen: Unacceptable

Slides
Room temperature: 30 days
Refrigerated: 30 days
Unacceptable

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Baked or melted slides • Previously stained slides • Cytospins • Tissue types other than lung cancer specimens • Cytology cell block • Decalcified specimens • Fixatives other than formalin

Methodology
Immunohistochemical Stain

Setup Schedule

Set up: Mon-Fri; Report available: 4-6 days

Reference Range

See Laboratory Report

Clinical Significance

TECENTRIQ is the first FDA-approved anti-PD-L1 cancer immunotherapy which is indicated for the treatment of patients with metastatic non-small cell lung cancer (NSCLC) who have disease progression during or following platinum- containing chemotherapy. Determining a patient's PD-L1 expression level can provide insight into the survival benefit that may be achieved from treatment with TECENTRIQ. PD-L1 expression in ≥50% tumor cells (TC) or ≥10% tumor-infiltrating immune cells (IC) (lymphocytes, macrophages, dendritic cells, and granulocytes) determined by VENTANA PD-L1 (SP-142) Assay/Quest PD-L1 Lung (Atezolizumab) in non-small cell lung cancer tissue may be associated with enhanced overall survival from TECENTRIQ (atezolizumab).

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.