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Digoxin
Test Code418
CPT Codes
80162
Preferred Specimen
1 mL serum collected in a red-top tube (no gel)
Patient Preparation
Collect as a trough just prior to next dose
Minimum Volume
0.5 mL
Other Acceptable Specimens
Plasma collected in a sodium or lithium heparin (green-top), or EDTA (lavender-top), or fluoride oxalate (gray-top) tube
Transport Temperature
Room temperature
Specimen Stability
Room temperature: 5 days
Refrigerated: 10 days
Frozen: 30 days
Refrigerated: 10 days
Frozen: 30 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Serum separator tube (SST)
Methodology
Immunoassay (IA)
Setup Schedule
Set up: Mon-Sat; Report available: 1-2 days
Limitations
Spironolactone and some herbal drugs may interfere with this test.
Reference Range
0.8-2.0 mcg/L
Clinical Significance
Digoxin is a cardiac glycoside derived from the digitalis plant. It is used to treat congestive heart failure and atrial dysrhythmias. Digoxin levels are monitored to assure adequate therapeutic levels are achieved and to avoid toxicity.
