Matrix Metalloproteinase-9 (MMP-9)

Test Code

91237

CPT Codes
83520

Preferred Specimen

1 mL serum

Minimum Volume

0.5 mL

Transport Container

Plastic screw-cap vial

Transport Temperature

Frozen

Specimen Stability

Room temperature: 4 hours
Refrigerated: 24 hours
Frozen: 30 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Received room temperature • Gross hemolysis

Methodology
Immunoassay (IA)

FDA Status
The performance characteristics of this test were determined by Pan Laboratories, Irvine, CA. It has not been cleared or approved by the U.S. Food and Drug Administration.

Setup Schedule

Set up: Wed; Report available: 3-8 days

Reference Range

0-900 ng/mL

Clinical Significance

Matrix metalloproteinases (MMPs) are a family of Zinc-dependent endopeptidases that degrade extracellular matrix proteins. Human MMP-9 Matrix metalloproteinase-9 (Gelatinase-B), with a molecular weight of 82 Kd, is inhibited by TIMP-1 and alpha 2 macroglobulin. MMP-9 is secreted by tumor cells, endothelial cells, fibroblasts and leucocytes.MMP-9 is involved in inflammation, tissue modeling, wound healing and processing of cytokines. Expression of MMP-9 correlates with abnormal collagen deposition that accompanies pancreatic cancer, with the metastasis to lymph nodes by human breast cancer cells and invasion of regional vessels in giant cell tumors of bones. MMP-9 is elevated in saliva in patients with gingivitis and periodontal diseases.

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.