Dengue Virus NS1 Antigen

Test Code

92942

CPT Codes
87449

Preferred Specimen

0.5 mL serum

Minimum Volume

0.1 mL

Transport Container

Transport tube

Transport Temperature

Room temperature

Specimen Stability

Room temperature: 7 days
Refrigerated: 14 days
Frozen: 30 days

Methodology
Immunoassay (IA)

FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Setup Schedule

Set up: Mon-Thurs; Report available: 2-6 days

Reference Range

NS1 Antigen Index

<1.00

Interpretive Criteria

<1.00	Negative
≥1.00	Positive

Dengue NS1 is a nonstructural glycoprotein found in the sera of recently-infected individuals between day 1 and day 9 after onset of symptoms. Thus, NS1 antigen detection can serve as an effective bridge between dengue RNA detection (usually negative by day 5) and dengue IgM detection (may not be positive until day 6) for identifying acute dengue virus infection. The assay detects NS1 antigen from all 4 dengue serotypes, precluding identification of the serotype responsible for current infection.

Clinical Significance

Dengue NS1 antigen is found in serum during the acute phase of dengue virus infection, typically during days 1-9 after onset of symptoms. NS1 antigen may be positive when RNA and/or IgM detection assays are negative.

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.