17-Hydroxy Progesterone, Urine

Test Code
39488

CPT Codes
83498<br /> This test is not available for New York patient testing.

Preferred Specimen
10 mL aliquot of a 24 hour urine submitted in a plastic, leak-proof container

Minimum Volume
5 mL

Other Acceptable Specimens
10 mL random urine

Instructions
Patient should not be on any Corticosteroid, ACTH, Estrogen, or Gonadotropin medications, if possible, for at least 48 hours prior to collection of specimen. No special preservatives are required.

Store specimens refrigerated during collection. Specimens should be frozen prior to shipping.
Note: Ship specimens frozen on dry ice. Provide the total volume.

Transport Temperature
Frozen

Specimen Stability
Room temperature: 1 hour
Refrigerated: 4 days
Frozen: 6 months

Methodology
Radioimmunoassay (RIA) following Extraction

Setup Schedule
Set up: Test batched 1-5 times per week; Report available: 10 days

Reference Range
Pediatric
Newborns and Infants 3 Days-1 Year up to 50 ng/24 hrs
Children 1-8 years up to 300 ng/24 hrs

Adult
Male up to 2.0 ug/24 hrs
Female up to 4.5 ug/24 hrs


Clinical Significance
17-Hydroxy Progesterone is a steroid derived primarily from enzymatic metabolism of progesterone and 17-Hydroxy Pregnenolone. It is converted enzymatically to androstenedione and 11-Deoxycortisol. It is produced in both the gonads and adrenal glands. It is excreted into the urine in conjugated and unconjugated forms of 17-Hydroxy Progesterone and as pregnanetriol. This assay measures the total of the conjugated and unconjugated forms. It is stimulated by ACTH and suppressed by dexamethasone. Levels of urine 17-Hydroxy Progesterone are greatly increased in patients with polycystic ovarian disease and congenital adrenal hyperplasia and show exaggerated responses to ACTH in these cases. 17-Hydroxy Progesterone is the marker steroid for determining cases of 21 alpha-hydroxylase deficient congenital adrenal hyperplasia. Urine levels are frequently elevated in patients with idiopathic hirsutism.



The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.