Neurokinin A (Substance K)

Test Code

17089

CPT Codes
83519

Preferred Specimen

3 mL frozen plasma collected in a 10 mL InterScience Institute's Z-tube ™ Preservative

Patient Preparation
Patient should not be on any medications that affect hypertension, gastrointestinal functions or pain relievers, if possible, for at least 48 hours prior to collection of specimen.

Minimum Volume

1 mL

Other Acceptable Specimens

For tumor/tissue and various fluids (i.e. CSF, peritoneal, synovial, etc.) contact Inter Science for requirements and special handling.

Instructions

Collect 10 mL blood directly into ISI's Z-tube™ Preservative and separate as soon as possible. Freeze plasma immediately after separation. Special Z-tube™ Preservatives are available from Inter Science Institute (ISI).

Note: One Z-tube™ may be shared for up to three tests. After centrifuging tube, aliquot 1mL per test in separate vials, mark with name of test and freeze.

Transport Temperature

Frozen

Specimen Stability

Room temperature: Unacceptable
Refrigerated: Unacceptable
Frozen: 1 month

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Received room temperature • Received refrigerated • Not collected in a Z-tube™

Methodology
Direct Radioimmunoassay

Setup Schedule

Set up: Mon-Fri; Report available: 5-7 business days (after set up)

Reference Range

Up to 40 pg/mL

Clinical Significance

Neurokinin A is a ten amino acid putative transmitter synthesized in the neurons it is present in. Neurokinin A is a member of the family called Tachykinins which also include Neurokinin B, Substance P, Physalaemin, and Eledoisin. Neurokinin A shares 6 of 10 peptide homologies with Neurokinin B even though they are produced by different genes. Neurokinin A is also very similar in structure to Substance P and produces some of the same biological actions as Substance P. Neurokinin A is a potent bronchoconstrictor. In the gut, Neurokinin A is produced by the intrinsic enteric nervous system.

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.