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Growth Hormone Binding Protein
Test Code18407
CPT Codes
83520<br>Restricted Client Code
Preferred Specimen
0.3 mL serum
Minimum Volume
0.1 mL
Instructions
Allow a minimum clotting time of 30 to 60 minutes with serum separation within 2 hours of collection. Send serum in a plastic transport tube.
Transport Temperature
Room temperature
Specimen Stability
Room temperature: 7 days
Refrigerated: 14 days
Frozen: 14 days
Refrigerated: 14 days
Frozen: 14 days
Methodology
Enzyme-Linked Immunosorbent Assay (ELISA)
FDA Status
This test was performed using a kit that has not been cleared or approved by the FDA. The analytical performance characteristics of this test have been determined by Esoterix. This test should not be used for diagnosis without confirmation by other medically established means.
Setup Schedule
Set up: Varies; Report available: 8-11 days
Reference Range
11-26 ng/mL
Clinical Significance
Reduced or absent GHBP is found in GH insensitivity due to inactivating receptor binding mutations as typified by Laron dwarfism. The most clinically relevant use of GHBP measurements is to confirm suspected Laron dwarf GH insensitivity due to genetic GH receptor defect. Other forms of GH receptor insensitivity, however may have normal or high GHBP levels. The levels of GHBP may be explained by the underlying mechanism for insensitivity, accordingly, inability to dimerize, errors in the trans-membrane structure, or in downstream actions may have high or normal GHBP levels.
Studies show that GHBP levels decrease in acromegaly, with normalization on successful treatment. The converse is not true-high GHBP levels are not found associated with GH deficiency.
Studies show that GHBP levels decrease in acromegaly, with normalization on successful treatment. The converse is not true-high GHBP levels are not found associated with GH deficiency.
