Aldosterone, Peripheral Adrenal Vein, 10 Minutes

Test Code

14043

CPT Codes
82088<br>Limited Access Code

Preferred Specimen

1 mL serum collected in a red-top tube (no gel)

Minimum Volume

0.25 mL

Other Acceptable Specimens

Plasma collected in: EDTA (lavender-top) tube, sodium heparin (green-top) tube or lithium heparin (green-top) tube

Instructions

Serum separator tubes are unacceptable. Draw blood in a no- additive (red-top) tube. Separate serum after clotting. Do not submit glass tubes. Draw "upright" samples at least 1/2 hour after patient sits up.

Transport Container

Transport tube

Transport Temperature

Refrigerated (cold packs)

Specimen Stability

Room temperature: 4 days
Refrigerated: 7 days
Frozen: 28 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Moderate to gross hemolysis • Serum separator tubes (SST)

Methodology
Chromatography • Mass Spectrometry (MS)

FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Setup Schedule

Set up: Mon-Sat; Report available: 3-5 days

Reference Range

(Unit of measure: ng/dL)
Adult Reference Ranges for Aldosterone, LC/MS/MS:
Upright 8:00-10:00 am < or = 28 ng/dL
Upright 4:00-6:00 pm < or = 21 ng/dL
Supine 8:00-10:00 am 3-16 ng/dL

Pediatric Reference Ranges for Aldosterone, LC/MS/MS:
1-12 months: 2-70 ng/dL
1-4 years: 2-37 ng/dl
5-9 years: < or = 9 ng/dL
10-13 years: < or = 21 ng/dL
14-17 years: < or = 35 ng/dL

Premature infants
(31-35 weeks)**: < or = 144 ng/dL
Term infants**: < or = 217 ng/dL

Tanner Stages:
II-III Males: 1-13 ng/dL
II-III Females: 2-20 ng/dL
IV-V Males: 3-14 ng/dL
IV-V Females: 4-32 ng/dL

**Pediatric data from J Clin Endocrinol Metab. 1992;75:1491 and J CLin Endocrinol Metab. 1989; 69;1133-1136.

Clinical Significance

Approximately 1-2% of individuals with primary hypertension have primary hyperaldosteronism characterized by hypokalemia (low potassium) and low direct renin. Because serum aldosterone concentrations vary due to dietary sodium intake and body position, some physicians prefer measurement of 24-hour urine concentrations for aldosterone.

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.