Alzheimer's Disease Evaluation, CSF

Test Code

13736

CPT Codes
83520 (x3)<br>Restricted Client Code

Preferred Specimen

2.5 mL CSF collected in a low bind polypropylene tube

Minimum Volume

1.5 mL

Instructions

1. Perform lumbar puncture and discard the first 1 to 2 mL of cerebrospinal fluid (CSF).
2. Collect CSF directly into one of the listed collection tubes until the tube is at least 50% full.*
3. Send CSF specimen in original collection tube. Do not aliquot.

*The Alzheimer's Association consensus protocol for handling of CSF for clinical measurements of Abeta42 and tau recommends using the drip method for CSF collection and directly collecting into a low bind polypropylene tube. Although some clinicians prefer the syringe pull method due to speed of collection, the drip method reduces the risk of Abeta42 binding to the plastic of any syringe used.

Note: Polystyrene collection tubes are not acceptable. Exposure of CSF to polystyrene tubes may result in falsely low Abeta42 concentrations. For more information see Cautions.

Transport Temperature

Refrigerated (cold packs)

Specimen Stability

Room temperature: 12 hours
Refrigerated: 14 days
Frozen: 60 days

Methodology
Electrochemiluminescence (ECLIA)

Setup Schedule

Set up: Tues, Fri; Report available: 1-4 days

Reference Range

See Laboratory Report

Clinical Significance

Assessment of adults with cognitive impairment being evaluated for Alzheimer disease and other causes of cognitive Impairment. These assays should not be used to predict the development of dementia or other neurologic conditions or to monitor response to therapies.

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.