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| A B C D E F G H I J K L M N O P Q R S T U V W X Y Z # |
Acetylcholine Receptor Binding Antibody with Reflex to MuSK/LRP4 Antibodies
Test Code38359
CPT Codes
86041
Includes
If the Acetylcholine Receptor Binding Antibody is Negative, then MuSK Antibody and LRP4 Antibody will be performed at an additional charge (CPT code(s): 86366, 86255)
Preferred Specimen
2 mL serum
Minimum Volume
0.5 mL
Instructions
Allow blood to clot at room temperature. Serum should be separated from cells within one hour.
Please label each specimen tube with two forms of patient identification. These forms of identification must also appear on the requisition form.
Please label each specimen tube with two forms of patient identification. These forms of identification must also appear on the requisition form.
Transport Container
Transport tube
Transport Temperature
Refrigerated (cold packs)
Specimen Stability
Room temperature: 72 hours
Refrigerated: 14 days
Frozen: 25 days
Refrigerated: 14 days
Frozen: 25 days
Methodology
Immunofluorescence Assay (IFA) • Radioimmunoassay (RIA)
Setup Schedule
Set up: Varies; Report available: 7-14 days
Reference Range
See Laboratory Report
Clinical Significance
Detects binding antibodies to the acetylcholine receptor (anti-AChR) by a quantitative radioimmunoassay in the sera of patients with Myasthenia Gravis (MG). About 80% to 85% of patients with generalized MG and 50% to 75% of patients with ocular MG have anti-AChR. Negative anti-AChR results are reflexed to testing for anti-MuSK (muscle specific receptor tyrosine kinase) and anti-LRP4 (low density lipoprotein receptor-related protein 4). Approximately 8% to 10% of all MG cases and 20% to 50% of the generalized MG cases who lack binding anti-AChR have anti-MuSK. Anti-LRP4 antibodies are detected in the serum of approximately 9.2% (range 2% to 50%) of MG patients who are negative for both binding anti-AChR and anti-MuSK.
