PFAS (Forever Chemicals) 9 Panel

Test Code

13724

CPT Codes
82542<br>Restricted Client Code

Includes

MeFOSAA
PFHxS
Linear PFOA (n-PFOA)
Branched PFOA (Sb-PFOA)
PFDA
PFUnDA
Linear PFOS (n-PFOS)
Branched PFOS (Sm-PFOS)
PFNA

Preferred Specimen

2 mL serum collected in a red-top tube (no gel)

Minimum Volume

1 mL

Other Acceptable Specimens

Plasma collected in: EDTA (lavender-top) tube or EDTA (pink-top) tube • Serum collected in: No additive (royal blue-top) tube

Instructions

Sample collection devices coated with PTFE/Teflon® and PVDF should be avoided because of potential specimen contamination.

Transport Temperature

Room temperature

Specimen Stability

Room temperature: 30 days
Refrigerated: 30 days
Frozen: 30 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Gross hemolysis • Serum separator tube (SST) • Unspun whole blood samples • Non-approved tube types

Methodology
Mass Spectrometry

FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Setup Schedule

Set up: Tues, Sat; Report available: 10 days from receipt

Reference Range

See Laboratory Report

Clinical Significance

Polyfluorinated alkyl substances (PFAS) are man-made forever chemicals that have been used in industry and consumer products since the 1940s. They have been used in nonstick cookware, water-repellent clothing, stain resistant fabrics and carpets, and some cosmetics and firefighting foams. PFAS do not break down. Scientists are still learning about the health effects to PFAS exposure. Some studies have shown that PFAS exposure may impact many different body systems. This panel will follow guidance provided by the National Academies of Sciences, Engineering, and Medicine (NASEM) Guidance on PFAS Exposure, Testing, and Clinical Follow-Up (2022) report on which PFAS to test and the corresponding clinical reference ranges.

References
1. National Academies of Sciences, Engineering, and Medicine 2022. Guidance on PFAS Exposure, Testing, and Clinical Follow-Up. Washington, DC: The National Academies Press. https://doi.org/10.17226/26156
2. "What ATSDR is doing with PFAS Toxic Substances and Disease Registry, CDC, 14 July 2023, What ATSDR doing with PFAS

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.