Copper, Liver Tissue

Test Code

13241

CPT Codes
82525

Preferred Specimen

2 cm liver tissue collected with a 22-gauge needle or
1 cm liver tissue collected with an 18-gauge needle submitted in a trace metal-free (royal blue-top) tube

Patient Preparation
Gadolinium is known to interfere with most metal tests. If gadolinium-containing contrast media has been administered a specimen should not be collected for 96 hours.

Minimum Volume

2 mg

Other Acceptable Specimens

2 mg tissue in paraffin block (Note: if no more than 1 or 2 cuts have been made to it for slides)

Instructions

1. Two mg of liver tissue is required. This is typically a piece of tissue from a 22-gauge needle biopsy at least 2 cm long. If an 18-gauge needle is used, the tissue must be at least 1 cm in length.
2. Any specimen vial other than a Mayo metal-free vial used should be plastic, leached with 10% nitric acid for 2 days, rinsed with redistilled water, and dried in clean air.

Additional information: Paraffin blocks will be returned 3 days after analysis is complete.

Transport Container

See Collection Instructions

Transport Temperature

Refrigerated (cold packs)

Specimen Stability

Liver tissue
Room temperature: Unacceptable
Refrigerated: 10 days
Frozen: Unacceptable

Tissue Paraffin block
Room temperature: Indefinitely
Refrigerated: Indefinitely
Frozen: Indefinitely

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

All specimens will be evaluated at Mayo Clinic Laboratories for test suitability

Methodology
Inductively Coupled Plasma-Mass Spectrometry

FDA Status
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

Setup Schedule

Set up: Mon, Thurs; Report available: 3-6 days

Reference Range

<50 mcg/g dry wt

Clinical Significance

Diagnosing Wilson disease and primary biliary cirrhosis using liver tissue specimens.

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.