|
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z # |
Mutated Citrullinated Vimentin (MCV) Antibody
Test Code13238
CPT Codes
83520
Preferred Specimen
1 mL serum
Minimum Volume
0.5 mL
Instructions
Collection Draw whole blood using red-top tube or serum-separator tube
Transport Temperature
Room temperature
Specimen Stability
Room temperature: 7 days
Refrigerated: 14 days
Frozen: 6 months
Refrigerated: 14 days
Frozen: 6 months
Methodology
Enzyme Linked Immunosorbent Assay (ELISA)
Setup Schedule
Set up: Daily; Report available: 2-4 days
Reference Range
<20 U/mL
Clinical Significance
Anti-mutated citrullinated vimentin (MCV) antibody is one of several specific anti-citrullinated protein antibodies which may be used as a second-line marker of rheumatoid arthritis (RA), in addition to rheumatoid factor and anti-cyclic citrullinated peptide (CCP). MCV antibody is less specific than CCP but has a slightly higher sensitivity and the addition of MCV to CCP adds 5-10% sensitivity for the diagnosis of RA. MCV antibody positivity is also associated with more severe disease and greater radiologic progression.