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| A B C D E F G H I J K L M N O P Q R S T U V W X Y Z # |
Pepsinogen II
Test Code11261
CPT Codes
83519<br><strong>This test is not available for New York patient testing.</strong>
Preferred Specimen
3 mL serum
Patient Preparation
Patient should be fasting 10-12 hours prior to collection of specimen. Antacids or other medications affecting stomach acidity or gastrointestinal motility should be discontinued, if possible, for at least 48 hours prior to collection.
Minimum Volume
1 mL
Other Acceptable Specimens
Plasma EDTA
Other Acceptable: For tumor/tissue and various fluids (i.e., CSF, peritoneal, synovial, etc.) contact the Institute for requirements and special handling.
Other Acceptable: For tumor/tissue and various fluids (i.e., CSF, peritoneal, synovial, etc.) contact the Institute for requirements and special handling.
Instructions
3 mL serum or EDTA plasma should be collected and separated as soon as possible. Freeze specimens immediately after separation. Minimum specimen size is 1 mL.
Transport Container
Transport tube
Transport Temperature
Frozen
Specimen Stability
Room temperature: Unacceptable
Refrigerated: 24 hours
Frozen: 14 days
Refrigerated: 24 hours
Frozen: 14 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Hemolysis • Received room temperature or refrigerated • No urine and no freeze thaw cycle
Methodology
Radioimmunoassay (RIA)
Setup Schedule
Set up: Mon-Fri; Report available: 7 business days
Reference Range
| ≤22 ng/dL |
Clinical Significance
The Pepsinogens are gastric acid protease zymogens. They are divided into two distinct immunochemical groups. Pepsinogen I and II. Pepsinogen II is one of 4 aspartic proteinases: PG I, PG II, Cathepsin E and D. Pepsinogen II is produced primarily in the Oxyntic gland mucosa of the stomach, the gastric antrum and the duodenum. It is secreted mainly into the gastric lumen and into circulation. Pepsinogen II has little or no biological activity but in acid is converted to the active enzyme Pepsin which exhibits proteolytic actions. Unlike Pepsinogen I, Pepsinogen II is not normally found in the urine. Patients with pernicious anemia have low to non-detectable levels of Pepsinogen I but normal levels of Pepsinogen II. Pepsinogen II levels are slightly elevated in gastric ulcer. Patients with Zollinger-Ellison's syndrome exhibit greatly elevated levels.
