Voriconazole, Serum

Test Code

13234

CPT Codes
80285

Preferred Specimen

2 mL serum collected in a red top tube (no gel)

Minimum Volume

0.6 mL

Instructions

Centrifuge and aliquot serum into a plastic vial within 2 hours of collection

Transport Container

Transport tube

Transport Temperature

Refrigerated (cold packs)

Specimen Stability

Room temperature: 28 days
Refrigerated: 28 days
Frozen: 28 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Gross hemolysis • Grossly lipemic • Gross icterus • Serum gel/SST

Methodology
Liquid Chromatography Tandem Mass Spectrometry (LC/MS/MS)

FDA Status
This test was developed, and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

Setup Schedule

Set up: Daily; Report available: 1-2 days

Reference Range

1.0-5.5 mcg/mL

Trough level (ie, immediately before next dose) monitoring is recommended.

Clinical Significance

Monitoring trough levels of voriconazole is suggested for:
-Individuals with reduced liver function
-Individuals with cytochrome P450 (CYP) 2C19 alterations associated with poor metabolic function
-Patients taking other medications that affect CYP2C19 activity
-Patients experiencing potential toxicity

Monitoring trough levels may be reasonable in patients who are not responding optimally or have drug interactions that may decrease voriconazole levels or to ensure adequate oral absorption

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.