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Bilirubin, Total, body fluid
MessagePerformed in Chemistry
Test Code
BILITBF
Preferred Specimen
FLUID
Other Acceptable Specimens
None
FDA Status
FDA Approved
Setup Schedule
Daily, Sunday through Saturday
Report Available
Less than 4 hours
Reference Range
Performance characteristics for this test have been evaluated and verified by the laboratory. There is no established reference range for body fluids. Test results must be interpreted within the clinical context.
Clinical Significance
Measurement of the levels of bilirubin, an organic compound formed during the normal and abnormal destruction of red blood cells, is used in the diagnosis and treatment of liver, hemolytic, hematological, and metabolic disorders, including hepatitis and gall bladder blockage. Bilirubin is formed in the reticuloendothelial system during the degradation of aged erythrocytes. The heme portion from hemoglobin and form other hemecontaining proteins is removed, metabolized to bilirubin, and transported as a complex with serum albumin to the liver. In the liver, bilirubin is conjugated with glucuronic acid for solubilization and subsequent transport through the bile duct and elimination via the digestive tract. Diseases or conditions which, through hemolytic processes, produce bilirubin faster than the liver can metabolize it, cause the levels of unconjugated (indirect) bilirubin to increase in the circulation. Liver immaturity and several other diseases in which the bilirubin conjugation mechanism is impaired cause similar elevations of circulating unconjugated bilirubin. Bile duct obstruction or damage to hepatocellular structure causes increases in the level of both conjugated (direct) and unconjugated (indirect) bilirubin in the circulation.
