Cyclosporine A (Trough)

Test Code

CYCLO

Quest Code

8812

CPT Codes
80158

Preferred Specimen

2 mL whole blood collected in an EDTA (lavender-top) tube

Patient Preparation
Collect as a trough, 12 hours after last dose

Minimum Volume

1 mL

Transport Temperature

Room temperature

Specimen Stability

Room temperature: 7 days
Refrigerated: 7 days
Frozen: 30 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Clotted specimen

Methodology
Immunoassay (IA)

Setup Schedule

Set up: Daily; Report available: 2 days

Reference Range

No definitive therapeutic or toxic ranges have been established. Optimal blood drug levels are influenced by type of transplant, patient response, time post-transplant, co-administration of other drugs, and drug formulation. The following trough ranges are suggested guidelines:

Kidney Transplantation	100-200 mcg/L
Other Organ Transplantation	200-300 mcg/L

Clinical Significance

Cyclosporine (Cyclosporin A) is an immunosuppressant therapeutic agent used in the prevention of organ graft rejection. Measurement of blood levels is recommended due to the inter-individual variability of metabolism as well as the toxicity associated with excessive dosage.

Performing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly, VA 20153

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.