| A B C D E F G H I J K L M N O P Q R S T U V W X Y Z # |
Cholinesterase, Serum
Test CodeCHOLN
Quest Code
37965
CPT Codes
82480
Preferred Specimen
1 mL serum
Minimum Volume
0.5 mL
Instructions
Centrifuge and transfer serum specimens to clean, plastic, screw-cap vial(s).
Transport Container
Plastic screw-cap vial
Transport Temperature
Refrigerated (cold packs)
Specimen Stability
Room temperature: 21 days
Refrigerated: 21 days
Frozen: 30 days
Refrigerated: 21 days
Frozen: 30 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Hemolysis
Methodology
Spectrophotometric Kinetic
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Setup Schedule
Set up: Mon-Fri; Report available: Next day
Limitations
Results may be depressed in patients who consume oral contraceptives. Hepatic disease may cause up to a 70% decrease in enzyme levels. Cholinesterase may be slightly elevated in patients with obesity or diabetes.
Reference Range
| Male | 3342-7586 IU/L | ||
| Female | 2673-6592 IU/L | ||
Clinical Significance
This test may be used to detect exposure to or poisoning from organophosphate-based pesticides; to assess baseline levels before exposure to organophosphates; or to monitor cholinesterase levels in individuals who work with pesticides. This test is also used in the diagnosis of inherited pseudocholinesterase deficiency, for individuals with a family history who will be receiving the muscle relaxant succinylcholine during surgery [1].
The Cholinesterase, Serum assay is often used as part of the diagnostic evaluation for individuals who present with symptoms of pesticide poisoning. Symptoms of organophosphate poisoning can range from mild to severe and may include sweating, salivation, miosis, hypotension, urinary incontinence, mental confusion, gastrointestinal spasms, anxiety, insomnia, tremors, convulsions, respiratory depression, and circulatory collapse, among others [1,2].
This test is also used in the diagnosis of inherited pseudocholinesterase deficiency, an enzyme deficiency characterized by impaired metabolism of succinylcholine, a muscle relaxant for surgical anesthesia. Individuals with this disorder who receive succinylcholine are at risk for prolonged postsurgical apnea and paralysis lasting 2 or more hours [3]. Thus, testing may be helpful to evaluate individuals who present with these symptoms postsurgically, as well as those with a family history of pseudocholinesterase deficiency who are scheduled for surgery [1].
References
1. American Association of Clinical Chemistry. Cholinesterase tests. https://labtestsonline.org/tests/cholinesterase-tests. Accessed September 24, 2019.
2. Lessenger JE, Reese BE. J Am Board Fam Pract. 1999;12:307-314.
3. Soliday FK, et al. AANA J. 2010;78:313-320.
The Cholinesterase, Serum assay is often used as part of the diagnostic evaluation for individuals who present with symptoms of pesticide poisoning. Symptoms of organophosphate poisoning can range from mild to severe and may include sweating, salivation, miosis, hypotension, urinary incontinence, mental confusion, gastrointestinal spasms, anxiety, insomnia, tremors, convulsions, respiratory depression, and circulatory collapse, among others [1,2].
This test is also used in the diagnosis of inherited pseudocholinesterase deficiency, an enzyme deficiency characterized by impaired metabolism of succinylcholine, a muscle relaxant for surgical anesthesia. Individuals with this disorder who receive succinylcholine are at risk for prolonged postsurgical apnea and paralysis lasting 2 or more hours [3]. Thus, testing may be helpful to evaluate individuals who present with these symptoms postsurgically, as well as those with a family history of pseudocholinesterase deficiency who are scheduled for surgery [1].
References
1. American Association of Clinical Chemistry. Cholinesterase tests. https://labtestsonline.org/tests/cholinesterase-tests. Accessed September 24, 2019.
2. Lessenger JE, Reese BE. J Am Board Fam Pract. 1999;12:307-314.
3. Soliday FK, et al. AANA J. 2010;78:313-320.
Performing Laboratory
| Quest Diagnostics Nichols Institute |
| 14225 Newbrook Drive |
| Chantilly, VA 20153 |
