Oligoclonal Bands, CSF & Serum

Test Code

Quest Code

CPT Codes

Preferred Specimen
1 mL CSF collected in a sterile CSF collection tube #4 and 1 mL serum

Minimum Volume
0.5 mL

Both CSF & serum are required specimens. It is preferred that the collection date and time be the same for both; however, it is acceptable for them to be drawn within 48 hours of each other. If no serum is supplied, the client will be contacted to confirm the order.

CSF collection tube #4 is preferred. Submitting 4th lumbar puncture collection tube minimizes blood contamination.

Transport temperature: Refrigerate CSF specimens at 2-8°C in sterile, plastic CSF vial(s) and send refrigerated (cold packs) to the laboratory OR freeze CSF specimens at -20°C and send frozen samples to the laboratory on dry ice.

Transport Temperature
Refrigerated (cold packs)

Specimen Stability
Room temperature: 8 hours
Refrigerated: 5 days
Frozen: 14 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Received room temperature

Isoelectric Focusing (IEF)

Setup Schedule
Set up: Sun-Fri; Report available: 4-6 days

Reference Range

Clinical Significance
Oligoclonal bands are present in the CSF of more than 85% of patients with clinically definite multiple sclerosis (MS). To distinguish between oligoclonal bands in the CSF due to a peripheral gammopathy and oligoclonal bands due to local production in the CNS, serum and CSF should be tested simultaneously. Oligoclonal bands can however be observed in a variety of other diseases, e.g., subacute sclerosing panencephalitis, inflammatory polyneuropathy, CNS lupus, and brain tumors and infarctions.

Performing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly, VA 20153

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.