A B C D E F G H I J K L M N O P Q R S T U V W X Y Z # |
Lipoprotein Fractionation
Test CodeQuest Code
CPT Codes
82465, 83701, 84478
Includes
Triglycerides
HDL Cholesterol
LDL Cholesterol
VLDL, Calculated
Preferred Specimen
Patient Preparation
Triglyceride test only: Patient should fast 9-12 hours prior to collection.
As part of lipid panel testing: A fasting sample is not required.
Minimum Volume
Instructions
Transport Container
Transport Temperature
Specimen Stability
Refrigerated: 7 days
Frozen -20° C: 14 days
Frozen -70° C: 1 year
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Methodology
Ultracentrifugation Colorimetric Enzymatic
Setup Schedule
Reference Range
Clinical Significance
This panel measures serum concentrations of total cholesterol, triglycerides, high-density lipoprotein (HDL) cholesterol, and low-density lipoprotein (LDL) cholesterol and provides a calculated concentration of very low-density lipoprotein (VLDL) cholesterol. Comprehensive lipid assessment aids in evaluating cardiovascular disease (CVD) risk and the likelihood of an ischemic event. It is also useful for the prevention and management of atherosclerotic disease and diagnosis of metabolic syndrome [1].
CVD is the leading cause of death in the United States. Individuals with high LDL cholesterol and triglyceride levels are at elevated risk for developing CVD and having an ischemic event [2,3]. The American Heart Association recommends that Americans aged 20 and above have their lipid levels tested every 4 to 6 years. Children should have their cholesterol tested for the first time between ages 9 and 11 and again between ages 17 and 21. Testing should start earlier if there is a family history of high cholesterol [4].
Treatment with N-acetyl cysteine for acetaminophen overdose may generate a falsely low result for cholesterol [5]. Venipuncture immediately after or during administration of the painkiller metamizole (dipyrone) may also lead to falsely low results for cholesterol [6].
Note: Any or all individual tests from a panel can be ordered separately.
The results of this test should be interpreted in the context of pertinent clinical and family history as well as physical examination findings.
References
1. Stone NJ, et al. Circulation. 2014;129(25 Suppl 2):S1-S45.
2. CDC. Heart disease facts. Accessed January 3, 2022. https://www.cdc.gov/heartdisease/facts.htm
3. Arbel Y, et al. Card Diabetol. 2016;15:11.
4. Grundy SM, et al. Circulation. 2019;139(25):e1082-e1143.
5. Beckman Coulter AU analyzers. Instructions for use. Beckman Coulter Inc; 2015. Accessed January 19, 2023. https://www.beckmancoulter.com/wsrportal/techdocs?docname=/cis/BAOSR6X16/%25%25/EN_CHOL%20OSR%20General%20Chemistry.pdf
6. Gascon N, et al. Clin Chem. 1993;39(6):1033-1036.
Performing Laboratory
Quest Diagnostics Nichols Institute-San Juan Capistrano, CA |
33608 Ortega Highway |
San Juan Capistrano, CA 92675-2042 |