Imipramine & Desipramine, Serum

Test Code

Alias/See Also

Imipramine
Janimine
Tofranil

Quest Code
887

CPT Codes
80335

Includes

Imipramine
Desipramine
Total

Preferred Specimen

3 mL serum collected in a no additive (red-top) tube, transferred to a plastic screw-cap vial

Minimum Volume

1.5 mL

Other Acceptable Specimens

3 mL plasma collected in an EDTA (lavender-top) tube, transferred to a plastic screw-cap vial
3 mL plasma collected in a fluoride oxalate (gray-top) tube, transferred to a plastic screw-cap vial
3 mL plasma collected in a sodium heparin (green-top) tube, transferred to a plastic screw-cap vial

Patient Preparation
Collect at steady-state trough concentration. Specimen should be collected >12 hours after dose.

Transport Temperature

Refrigerated

Specimen Stability

Room temperature: 5 days
Refrigerated: 5 days
Frozen: 30 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Gross hemolysis
Collection in gel barrier tubes

Methodology
Liquid Chromatography / Tandem Mass Spectrometry (LC/MS/MS)

Setup Schedule

Monday-Thursday, Saturday a.m.
Friday a.m. and night

Report Available

Next day

Clinical Significance

Imipramine is a tricyclic antidepressnt drug used to treat depression. Therapeutic drug monitoring is used to optimize dose and to avoid toxicity.

Performing Laboratory
Quest Diagnostics Nichols Institute
Chantilly, VA

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.