Prolactin

Test Code
PROLQ


Alias/See Also
Prolactin

Quest Code
746


CPT Codes
84146

Preferred Specimen
1 mL serum collected in a serum separator tube (SST)


Minimum Volume
0.5 mL


Other Acceptable Specimens
1 mL serum collected in a no additive (red-top) tube, transferred to a plastic screw-cap vial

Patient Preparation
Overnight fasting is preferred.


Transport Temperature
Refrigerated


Specimen Stability
Room temperature: 5 days
Refrigerated: 7 days
Frozen: 28 days


Methodology
Immunoassay

Setup Schedule
Monday-Sunday all shifts


Report Available
Next day


Clinical Significance
During pregnancy and postpartum lactation, serum prolactin can increase 10- to 20-fold. Exercise, stress, and sleep also cause transient increases in prolactin levels. Consistently elevated serum prolactin levels (>30 ng/mL), in the absence of pregnancy and postpartum lactation, are indicative of hyperprolactinemia. Hypersecretion of prolactin can be caused by pituitary adenomas, hypothalamic disease, breast or chest wall stimulation, renal failure or hypothyroidism. A number of drugs, including many antidepressants, are also common causes of abnormally elevated prolactin levels. Hyperprolactinemia often results in galactorrhea, amenorrhea, and infertility in females, and in impotence and hypogonadism in males. Renal failure, hypothyroidism, and prolactin-secreting pituitary adenomas are also common causes of abnormally elevated prolactin levels.

Performing Laboratory
Quest Diagnostics Nichols Institute
Chantilly, VA




The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.