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Troponin I
MessageTest performed at York Hospital Laboratory.
Test Code
TROP
CPT Codes
84484
Preferred Specimen
0.3 mL plasma collected in lithium heparin (green-top) tube, collected in a gel separator tube
Other Acceptable Specimens
0.3 ml serum collected in a serum separator tube (SST).
Transport Temperature
Refrigerated
Specimen Stability
Room temperature: 2 hours
Refrigerated: 7 days
Frozen: 4 weeks
Refrigerated: 7 days
Frozen: 4 weeks
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Hemolyzed specimen
Methodology
Chemiluminescence
Setup Schedule
Daily
Report Available
Same Day
Available STAT 1/2 Hour
Available STAT 1/2 Hour
Reference Range
Normal <0.034 ng/mL
Diagnostic >=0.120 ng/mL
Diagnostic >=0.120 ng/mL
Clinical Significance
Clinical studies have demonstrated that cardiac Troponin I (cTnI) is detectable in the bloodstsream 4-6 hours after an acute myocardial infarction(AMI) and remains elevated for several days thereafter. Thus, cTnI elevation covers the diagnostic windows of both creatine kinase-MB (CK-MB) and lactate dehydrogenase (LDH). Further studies have indicated that cTnI has a higher clinical specificity for myocardial injury than does CK-MB.
Other conditions resulting in myocardial cell damage can contribute to elevated cTnI levels. Published studies have documented that these cconditions include, but are not limited to, sepsis, congestive heart failure, hypertension with left ventricular hypertrophy, hemodynamic compromise, myocarditis, mechanical injury including cardiac surgery, defibrillation and cardiac toxins such as anthracyclines.
Other conditions resulting in myocardial cell damage can contribute to elevated cTnI levels. Published studies have documented that these cconditions include, but are not limited to, sepsis, congestive heart failure, hypertension with left ventricular hypertrophy, hemodynamic compromise, myocarditis, mechanical injury including cardiac surgery, defibrillation and cardiac toxins such as anthracyclines.
