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Folate
MessageTest performed at York Hospital Laboratory.
Test Code
FOL
Alias/See Also
Folic Acid
CPT Codes
82746
Preferred Specimen
0.3 mL serum collected in a serum separator tube (SST)
Other Acceptable Specimens
0.3 mL serum collected in a no additive (red-top) tube, transferred to a plastic screw-cap vial
0.3 mL plasma collected in a lithium heparin (green-top) gel separator tube
0.3 mL plasma collected in a lithium heparin (green-top) gel separator tube
Instructions
Protect specimens from prolonged exposure to light and direct sunlight.
Transport Temperature
Refrigerated
Specimen Stability
Room temperature: 4 hours
Refrigerated: 7 days
Frozen: 4 weeks
Refrigerated: 7 days
Frozen: 4 weeks
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Hemolyzed specimens
Methodology
Chemiluminescence
Setup Schedule
Daily
Report Available
Next Day
Reference Range
2.76-20.00 ng/mL
Clinical Significance
Folate deficiency can lead to macrocytic (megaloblastic) anemia. Folate is obtained from dietary sources including fruits, green and leafy vegetables, yeast and organ meats. Low folate intake, malabsorption as a result of gastrointestinal diseases, pregnancy and the use of drugs such as phenytoin, oral contraceptives and excessive concentrations of alcohol are causes of folate deficiency. Low serum folate concentrations are an early indication of folate depletion and precede depletion in the tissues. Adequate folate concentrations during pregnancy are also important in the prevention of neural tube defects (NTD) in infants.