Alkaline Phosphatase

Message

Test performed at York Hospital Laboratory.

Test Code

ALKP

Alias/See Also

Alk Phos

CPT Codes
84075

Preferred Specimen

0.2 mL serum collected in a serum separator tube (SST)

Other Acceptable Specimens

0.2 mL serum collected in a no additive (red-top) tube, transferred to a plastic screw-cap vial
0.2 mL plasma collected in a lithium heparin (green-top) gel separator tube

Instructions

Separate serum or plasma from the cells within 4 hours of collection.

Transport Temperature

Refrigerated

Specimen Stability

Room temperature: 4 days
Refrigerated: 4 days
Frozen: 4 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Hemolyzed specimen

Methodology
Spectrophotometry

Setup Schedule

Daily

Report Available

Next Day Available STAT 1/2 Hour

Reference Range

Age	Alk Phos (U/L) Male	Alk Phos (U/L) Female
<3 Years	145 - 320	145 - 320
4-6 Years	150 - 380	150 - 380
7-9 Years	175 - 420	175 - 420
10-11 Years	135 - 530	130 - 560
12-13 Years	200 - 495	105 - 420
14-15 Years	130 - 525	70 - 230
16-19 Years	65 - 260	50 - 130
Adult	38 - 126	38 - 126

Clinical Significance

Serum alkaline phosphatase may be elevated in increased bone metabolism, for example, in adolescents and during the healing of a fracture; primary and secondary hyperparathyroidism; carcinoma metastatic to bone; osteogenic sarcoma; and Hodgkin's disease if bones are invaded. Hepatobiliary diseases involving cholestatis, inflammation, or cirrhosis increase alkaline phoshatase activity; alkaline phosphatase may be increased in renal infarction and failure and in the complications of pregnancy. Low alkaline phosphatase activity may occasionally be seen in hypothyroidism.

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.