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Antibody Screen, Indirect
MessageTest performed at York Hospital Laboratory.
Test Code
ABS
CPT Codes
86850
Preferred Specimen
12 mL whole blood collected in (2) EDTA (pink-top) tubes
Instructions
Specimen must be labeled with: (1) full patient name (2) date of birth (3) medical record number (inpatients only) (4) date and time of collection (5) identification of person who identified the patient (full legible signatures and/or employee ID number is required. This labeling must occur in the presence of the patient.) The signature may be either printed or scripted but MUST be legible and written in indelible ink. If patient is a transfusion candidate, order TS.
Transport Temperature
Refrigerated
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Hemolyzed specimen
Methodology
Hemagglutination
Setup Schedule
Daily
Report Available
Next Day
Reference Range
Negative Critical Values Positive
Clinical Significance
Antibody screening is for the detection of allo- or autoantibodies direct against red blood cell antigens in the settings of pretransfusion testing. Transfusion and pregnancy are the primary means of sensitization to red cell antigens. Allo-antibodies may cause hemolytic disease of the newborn or hemolysis of transfused donor red blood cells. Autoantibodies react against the patient's own red cells as well as the majority of cells tested. Autoantibodies can be clinically benign or can hemolyze the patient's own red blood cells, such as in cold agglutinin disease or autoimmune hemolytic anemia.