Chromosome Analysis, Amniotic Fluid

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For Specimen Integrity during Extreme Weather see the “Lockbox Usage in Extreme Weather” document at the top of this page.

Test Code

CHRMAM

Alias/See Also

14590

CPT Codes
88235, 88269, 88280

Physician Attestation of Informed Consent

This germline genetic test requires physician attestation that patient consent has been received if ordering medical facility is located in AK, DE, FL, GA, IA, MA, MN, NV, NJ, NY, OR, SD or VT or test is performed in MA.

Preferred Specimen

20 mL amniotic fluid collected in a sterile, screw-cap container

Minimum Volume

5 mL

Instructions

30 mL is preferred if other testing, e.g. microarray, FISH is ordered.

Ship at room temperature. Do not Freeze.
Send all tubes to lab (supernatant for AFP will be split by cytogenetics lab).

Please contact the laboratory Genetic Counselor at 1-866-GENEINFO (1-866-436-3463) with any questions.

Transport Temperature

Room temperature

Specimen Stability

Room temperature: Preferred
Refrigerated: Acceptable
Frozen: Unacceptable

Specimen viability decreases during transit. Send specimen to testing lab for viability determination. Do not freeze. Do not reject.

Methodology
Culture • Karyotype • Microscopy

Setup Schedule

Set up: Daily; Report available: 9-12 days

Clinical Significance

This test will detect chromosome abnormalities of the fetus including numerical, structural, and mosaic abnormalities. Chromosome analysis will also reveal fetal sex and sex chromosome abnormalities. Indications for prenatal chromosome analysis may include advanced maternal age, abnormal fetal ultrasound, abnormal maternal serum screen, abnormal cell-free DNA results, history of a previous child with a chromosome abnormality, or a parent who carries a balanced chromosomal rearrangement or has another chromosome abnormality.

Performing Laboratory
Quest Diagnostics Nichols Institute
33608 Ortega Highway
San Juan Capistrano, CA 92690-6130

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.