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| A B C D E F G H I J K L M N O P Q R S T U V W X Y Z # |
AccuType® IL28B
Test CodeIL28B
Quest Code
90251
CPT Codes
81283
Physician Attestation of Informed Consent
This germline genetic test requires physician attestation that patient consent has been received if ordering medical facility is located in AK, DE, FL, GA, IA, MA, MN, NV, NJ, NY, OR, SD or VT or test is performed in MA.
Preferred Specimen
5 mL whole blood collected in an EDTA (lavender-top) tube
Minimum Volume
2 mL
Other Acceptable Specimens
Whole blood collected in: ACD solution A (yellow-top) tube or ACD solution B (yellow-top) tube
Buccal swab collected in: DNA Genotek Oracollect Kit or Celera DNA Collection Kit (follow collection kit instructions)
Patient preparation: Do not eat immediately prior to sample collection. If patient has eaten recently, rinse mouth with plain water.
Buccal swab collected in: DNA Genotek Oracollect Kit or Celera DNA Collection Kit (follow collection kit instructions)
Patient preparation: Do not eat immediately prior to sample collection. If patient has eaten recently, rinse mouth with plain water.
Transport Container
EDTA (lavender-top) tube
Transport Temperature
Room temperature
Specimen Stability
Whole blood
Room temperature: 8 days
Refrigerated: 8 days
Frozen: Unacceptable
Buccal swab
Room temperature: 14 days
Refrigerated: Unacceptable
Frozen: Unacceptable
Room temperature: 8 days
Refrigerated: 8 days
Frozen: Unacceptable
Buccal swab
Room temperature: 14 days
Refrigerated: Unacceptable
Frozen: Unacceptable
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Received frozen • Buccal swab received refrigerated • Incorrect collection device • Liquid has leaked from container/no liquid present
Methodology
Real-Time Polymerase Chain Reaction
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
This test code is for non-New York patient testing. For New York patient testing, use test code 90252.
Setup Schedule
Sat-fri
Report Available
3 days
Reference Range
See Laboratory Report
Clinical Significance
The C polymorphism in rs12979860 is strongly associated with a two fold greater sustained virological response in European, African American, and Hispanic populations. Knowledge of the host genotype of patients infected with HCV will aid in the clinical decision to initiate treatment with PegIFN and RBV (a 48 week course of interferon and ribavirin which has limited efficacy and is often poorly tolerated due to side effects that prevent patients from finishing treatment).
Performing Laboratory
| Quest Diagnostics Nichols Institute-San Juan Capistrano, CA |
| 33608 Ortega Highway |
| San Juan Capistrano, CA 92675-2042 |
