Acetylcholinesterase, Qualitative [4929X]

Test Code
4929X

Includes
This test is automatically performed on all Alpha-Fetoprotein amniotic fluids when the MoM is greater than 1.99.

Preferred Specimen
1.5 mL unpreserved amniotic fluid, submitted in a sterile, plastic, leak-proof container

Minimum Volume
0.5 mL

Transport Temperature
Room temperature or refrigerated (cold packs)

Specimen Stability
Room temperature: 14 days
Rrefrigerated: 4 months
Frozen: 3 years

Methodology
Gel Electrophoresis

Limitations
Substantial hemorrhage into amniotic fluid may cause AChE and AFP to increase.

Reference Range
Negative

Clinical Significance
The presence of acetylcholinesterase (AChE) activity in amniotic fluid is associated with open neural tube defects. The AChE assay is useful in assessing the evaluation of a positive AFP result and in evaluating amniotic fluid samples with elevated AFP concentrations. There is indication that the AChE assay exhibits fewer false positives than the AFP assay. The two assays together are complimentary in the clinical assessment of neural tube defects.

Performing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly, VA 20153



The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.