| A B C D E F G H I J K L M N O P Q R S T U V W X Y Z # |
Blastomyces Antibody, Complement Fixation, Serum [933X]
Test Code11908
Preferred Specimen
1 mL serum
Minimum Volume
0.1 mL
Instructions
Note: For CSF use test code 5294 - Blastomyces Antibody Compliment Fixation, CSF.
Transport Temperature
Room temperature
Specimen Stability
Room temperature: 7 days
Refrigerated: 14 days
Frozen: 30 days
Refrigerated: 14 days
Frozen: 30 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis • Grossly icteric
Methodology
Complement Fixation
Setup Schedule
Set up: Tues-Sat; Report available: 3-5 days
Reference Range
| <1:8 | Antibody not detected |
Clinical Significance
Although titers of 1:8 and greater are considered positive, confirmed serological diagnosis of blastomycosis by the CF test requires a fourfold or greater increase in titer between acute and convalescent specimens, and lack of corresponding titers to C. immitis and H. capsulatum. Specificity can only be demonstrated by immunodiffusion procedures. A negative CF test does not rule out the diagnosis of active blastomycosis, as fewer than 50% of sera from patients with proven blastomycosis are positive by this assay.
Performing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly, VA 20153
